No products in the cart.
RETINOL+
FREQUENTLY ASKED QUESTIONS
________
____
Retinol belongs to a family of molecules called Retinoids. Retinoids may be natural (retinol) or synthetic. Some retinoids are used in prescription medicinal creams (e.g. Tretinoin and Isotretinoin) for a wide range of indications, such as skin ageing and photo damage, disorders of skin pigmentation, acne, and other indications.
Retinol shares the same activity as retinoids, only milder and without the risk of side effects including skin irritation. This happens because Retinol slowly metabolises to retinoic acid, delivering therefore small amounts of retinoic acid during a relatively long period of time.
As a result, Retinol+ offers a robust effect and complete protection to your skin.
Retinol+ covers your skin needs, as these are expected to appear in various age bands. For example:
In your 30s, Retinol+ will effectively improve or prevent the appearance of fine lines, especially those appearing around your eyes.
In your 40s, Retinol+ will confront possible sagging, irregular skin pigmentation, and first fine wrinkles. Consider using additional moisturisers, since at this age the skin tends to dehydrate and sun exposure cumulative effects are usually visible.
In your 50s and over, use Retinol+ for deep wrinkles, and loss of firmness on your face and neck. Retinol+ penetrates deep into the skin and increases cellular regeneration and collagen production. At this age, you must take into account that menopause may aggravate skin ageing.
RETINOL is suitable for both MEN & WOMEN.
Retinol+ formulation is a result of extensive scientific and clinical research, carefully undertaken by LABORATOIRES DERMAGEN.
LABORATOIRES DERMAGEN is a science based EU company, operated by Health Care Professionals and Cosmetologists. All formulated products are based on documented scientific and clinical evidence.
Ingredients are purchased by world leading manufacturers and their quality is extensively tested. For example, Retinol used in Retinol+ is in stabilized form that guarantees stability and long term efficacy, since low quality Retinol is easily oxidisable and its activity quickly diminishes.
The formulation of Retinol+ is unique and incorporates the Monodose system that protects Retinol and the other ingredients from oxidation and breakdown due to light and oxygen exposure. The single dose ampoules are completely protect the formulation and offer increased stability and assurance of continued efficacy.
Retinol+ formulation and intrinsic retinol characteristics ensures high skin penetration and delivery of Retinol to the lower skin layers (Dermis).
Retinol+ formulation is designed to achieve complete absorption and quick delivery of the active ingredients deep into the skin dermis, where action matters the most.
Retinol+ formulation incorporates other active ingredients (refer above) as the anti-oxidant DMM Chromanol that acts simultaneously with Retinol to reverse photoaging and correct wrinkles.
The strength of retinol and other active ingredients have been scientifically and evidence-based selected, as to provide maximum benefits and excellent good skin tolerance.
No side effects will appear with the correct use of Retinol+.
Some effects that you may observe, such as a sense of warmness, red skin, benign sting are quite normal and a result of the action of Retinol+. These effects may be more intense during the start of the therapy and tend to disappear with normal use.
Applying too much Retinol+ may provoke itching and scaling.
It is preferable and recommended to use Retinol+ during the night. It is also recommended to use a sunscreen product, with adequate protection factor (at least SPF 15) in the morning.
Avoid using Retinol+ during pregnancy or use it only upon recommendation by your Physician/Dermatologist.
Should any side effects become severe, avoid using Retinol+ and talk to your Dermatologist.
If you have Dry Skin, take into consideration that Retinol has a drying effect. Retinol+ formulation provides moisturising activity to counteract this retinol characteristic by incorporating emollients and ceramides in the formulation. Retinol+ is designed to deliver ingredients deep in the skin dermis, minimising thus the drying of the skin. Nonetheless, if you feel that your skin is getting dry, use a moisturizing product (e.g. a moisturizing night cream) with your therapy.
If you have Oily Skin, take into account that retinol effectively controls oil production and oily skins may tolerate higher doses of retinol.
If you have a Sensitive Skin, take into account that Retinol+ is formulated especially to care for sensitive skins. Retinol+ does not contain any sensitising materials, aromas, parabens or genetically modified ingredients. The Retinol content of Retinol+ formulation is meticulously selected as to exert full activity without providing risks to sensitive skins.
If you have acne-prone skin, take into consideration that Retinol+ can effectively improve your condition because of its exfoliating activity.
If you have Dry skin, consider using a good moisturizer in parallel with Retinol+.
Preferably use sunscreens if you are engaged in outdoor activities during the day (at least SPF 15).
Use of products with antioxidants (oral and/or topical), such as Vitamin C, Vitamin E, Co Q10, Green Tea, etc. is usually recommended in parallel to the use of Retinol products. With Retinol+ therapy, such complimenting activity is not routinely required, since Retinol+ already contains antioxidant ingredients (DMM Chromanol).
However, a product everyone must use as from the age of around 30, when expression lines make their initial appearance on skin, is EXPRESSION WRINKLES REDUCER. This product to effectively reduces the appearance of expression wrinkles, and is a monodose advanced formulation with 10 % ARGIRELINE®.
Skin ageing is a very complex, multi-factorial process, continuously researched by scientists. The results of skin ageing are abnormal changes to the cells and tissues of the skin and lower skin layers (Epidermis and Dermis). Changes in Dermis (lower skin layer) make a much greater contribution to the overall appearance of the skin, though skin ageing is also apparent in Epidermis.
Sun exposure is responsible of almost 90% of premature skin ageing usually referred to as photoaging (all external factors responsible for skin ageing are referred as “extrinsic” ageing in contrast to normal skin ageing, referred also as “intrinsic” ageing). Photo damaging starts early in life and has a cumulative activity. UV radiation is without doubt the single major factor responsible for skin ageing.
The main clinical signs of photoaging are changes/irregular pigmentation, swollenness, deep wrinkles dryness, skin atrophy, skin roughness, laxity, telangiectasias, and premalignant lesions. These changes appear on the sun exposed areas of our body, such as face, neck, upper chest, hands and forearms. These changes are more visible when we compare people working outdoors (farmers, sailors, sunbathers, outdoor activities) and people working indoors.
In contrast, normal skin ageing (also known as “intrinsic” ageing) is characterised mainly by fine wrinkles, laxity, seborrheic keratosis (Not increased pigmentation and deep wrinkles that characterise photoaging).
UV radiation of sun light absorbed by skin, damages the DNA and generates some harmful substances (called Reactive Oxygen Species) that eventually decrease the number of fibroblasts, reduce the synthesis of elastin, and increase the breakdown of collagen and the formation of deep wrinkles.
Retinol+ effectively reverses photo damages generated by sunlight, which are responsible for the formation of deep wrinkles up to 90%.
Increased life expectancy and modern life-style (entertainment, summer vacations, etc.) are factors contributing to the appearance of skin ageing. Tobacco smoke, environmental pollution, malnutrition, alcohol consumption also contribute to premature skin ageing and wrinkles.
Genetic factors determine to some extent the early or late appearance of skin ageing. But, almost 90% of skin ageing is due to sun induced skin damages (Photoaging) and more specifically by UV radiation.
The main proposed mechanism of photo damage is the deleterious effect of UV radiation to the DNA by Reactive Oxygen Species (ROS), i.e. free radicals that are produced by UV damaged cells (oxidative cell metabolism). Free radicals damage the skin’s DNA, lipids and proteins, including Collagen. Collagen is responsible for skin’s integrity, firmness and elasticity. Damaging collagen leads to premature skin-ageing and the formation of wrinkles.
Sex hormones deficiency such as estrogen and progesterone (e.g. menopause) and testosterone cause skin dryness, wrinkles, epidermal atrophy, collagen breakdown and loss of elasticity.
Repetitive face movements may promote the appearance of wrinkles e.g. around the eyes -“crows feet”-, forehead, around the mouth, between eyebrows etc.
Sun Avoidance
Best practice is to avoid as much as possible exposure to sunlight (UVA and UVB radiation). More importantly, avoid sun exposure between 10:00 – 16:00 (midday) when sunlight is most intense. Avoid sunbathing and sun tanning beds which accelerate photoaging (“There is no such thing as a healthy tan”!).
Sunscreens
Use sunscreens when you are exposed to sunlight. Sunscreens efficacy is defined by their Sun Protection Factor (SPF). Use good quality sunscreens with an SPF of 15 or higher and apply frequently (every 2-3 hours) to all exposed body parts.
Take into consideration that SPF rating only confers protection against UVB and NOT against UVA. UVA blockers are nowadays available. Total blockers (such as Titanium dioxide and Zinc oxide) which are physical blockers or newer organic filters cover both UVA and UVB radiation spectrum.
Clothing
Consider wearing a hat, long sleeved, light coloured clothing of suitable materials that block UV radiation and allow the body to breathe.
Yes, there is! A vast number of articles, scientific studies, including clinical studies [double blind, placebo (vehicle)-controlled], were published proving the efficacy of Retinol in prevention and treatment of lines, wrinkles, skin ageing and in supporting acne treatment.
Well known are the studies conducted by the University of Michigan, proving retinol effectiveness, which shed more light on the mechanism of action (retinoic acid skin receptors).
The most powerful evidence in cosmetics effectiveness is clinical studies. A brief list of such studies proving the efficacy of Retinol follows:
1) Tucker-Samaras et al. A stabilized 0.1% retinol facial moisturizer improves the appearance of photo damaged skin in an eight-week, double blind, vehicle –controlled study. J Drugs Dermatol. 2009 Oct; 8(10):932-6
2) R.Kfi et al. Improvement of naturally aged skin with Vitamin A (Retinol) Arch Dermatol.2007; 143(5): 606-612
3) C.Stephanaki et al. Topical retinoids in the treatment of photoaging. J. Cosm. Dermatol.2005,4, 130-134.
4) Y.Shao et al. Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo.Int.J.Cosmet.Sci.2017, 39, 56-65
5) D.Rossetti et al. A novel anti-ageing mechanism for retinol: induction of dermal elastin synthesis and elastin fibre formation. Int.J.Cosmet.Sci.2011, 33, 62-69.
6) C.Zouboulis. Retinoids: Is there a new approach IFSCC Magazine-vol.3, no3/2000, 9-19
7) C.Ruamrak et al. Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment. Int.J.Cosmet. Sci. 2009, 31, 41-46.
8) J.Varani et al. Molecular mechanisms of intrinsic skin aging and retinoid-induced repair and reversal. 1998 .JID symposium proceedings.
9) R.Darlenski et al. Topical retinoids in the management of photo damage skin: From theory to evidence-based practical approach. Brit. J. Derm. 2010; 163 (6): 1157-1165
10) J.Varani et al. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin
J. Invest. Derm. 2000; 114 (3): 480-486
Worldwide there are no limits in the permitted concentration of Retinol to be used in cosmetic products with the exception of Canada whereas is permitted in concentrations equals or less than 1%.
However the Scientific Committee on Consumer Safety (SCCS) of the European Commission on OCT’ 06 . 2016 has concluded that Retinol is safe when used as cosmetic ingredient in face care products at the maximum concentration of 0.3 %.
It must be noted that this opinion has not affected yet any EU regulatory restrictions.
With thousands upon thousands of creams, serums etc claiming to turn back the clock at your skin, there’s only one active ingredient that really delivers on its promise Retinol.
Retinol is perhaps the best performing ingredient to effectively address the signs of premature ageing and photo damaged skin.
Retinol is able to tackle several different skin concerns at once including sun damage, fine lines, pores, acne prone skin and overall texture.
Retinol increases cell turnover, stimulates collagen and elastin production leaving your skin well hydrated, smoother and by inhibiting the production of melanin your skin is more luminous.
In conclusion Retinol it’s the closest thing to skincare miracle you’ll find.
YOUR PROBLEM WAS NOT SOLVED?
________
____
SEND US AN EMAIL
If you have any questions concerning our products or any other subject, please do not hesitate to contact us
SKINCARE ADVICE
We offer an innovative approach to skin treatment not only to minimize premature ageing but also to improve your skin’s condition
VISIT US
Visit us to learn more about our revolutionary approach to skin treatment and how it can enhance your skin’s beauty
Retinol belongs to a family of molecules called Retinoids. Retinoids may be natural (retinol) or synthetic. Some retinoids are used in prescription medicinal creams (e.g. Tretinoin and Isotretinoin) for a wide range of indications, such as skin ageing and photo damage, disorders of skin pigmentation, acne, and other indications.
Retinol shares the same activity as retinoids, only milder and without the risk of side effects including skin irritation. This happens because Retinol slowly metabolises to retinoic acid, delivering therefore small amounts of retinoic acid during a relatively long period of time.
As a result, Retinol+ offers a robust effect and complete protection to your skin.
Retinol+ covers your skin needs, as these are expected to appear in various age bands. For example:
In your 30s, Retinol+ will effectively improve or prevent the appearance of fine lines, especially those appearing around your eyes.
In your 40s, Retinol+ will confront possible sagging, irregular skin pigmentation, and first fine wrinkles. Consider using additional moisturisers, since at this age the skin tends to dehydrate and sun exposure cumulative effects are usually visible.
In your 50s and over, use Retinol+ for deep wrinkles, and loss of firmness on your face and neck. Retinol+ penetrates deep into the skin and increases cellular regeneration and collagen production. At this age, you must take into account that menopause may aggravate skin ageing.
RETINOL is suitable for both MEN & WOMEN.
Retinol+ formulation is a result of extensive scientific and clinical research, carefully undertaken by LABORATOIRES DERMAGEN.
LABORATOIRES DERMAGEN is a science based EU company, operated by Health Care Professionals and Cosmetologists. All formulated products are based on documented scientific and clinical evidence.
Ingredients are purchased by world leading manufacturers and their quality is extensively tested. For example, Retinol used in Retinol+ is in stabilized form that guarantees stability and long term efficacy, since low quality Retinol is easily oxidisable and its activity quickly diminishes.
The formulation of Retinol+ is unique and incorporates the Monodose system that protects Retinol and the other ingredients from oxidation and breakdown due to light and oxygen exposure. The single dose ampoules are completely protect the formulation and offer increased stability and assurance of continued efficacy.
Retinol+ formulation and intrinsic retinol characteristics ensures high skin penetration and delivery of Retinol to the lower skin layers (Dermis).
Retinol+ formulation is designed to achieve complete absorption and quick delivery of the active ingredients deep into the skin dermis, where action matters the most.
Retinol+ formulation incorporates other active ingredients (refer above) as the anti-oxidant DMM Chromanol that acts simultaneously with Retinol to reverse photoaging and correct wrinkles.
The strength of retinol and other active ingredients have been scientifically and evidence-based selected, as to provide maximum benefits and excellent good skin tolerance.
No side effects will appear with the correct use of Retinol+.
Some effects that you may observe, such as a sense of warmness, red skin, benign sting are quite normal and a result of the action of Retinol+. These effects may be more intense during the start of the therapy and tend to disappear with normal use.
Applying too much Retinol+ may provoke itching and scaling.
It is preferable and recommended to use Retinol+ during the night. It is also recommended to use a sunscreen product, with adequate protection factor (at least SPF 15) in the morning.
Avoid using Retinol+ during pregnancy or use it only upon recommendation by your Physician/Dermatologist.
Should any side effects become severe, avoid using Retinol+ and talk to your Dermatologist.
If you have Dry Skin, take into consideration that Retinol has a drying effect. Retinol+ formulation provides moisturising activity to counteract this retinol characteristic by incorporating emollients and ceramides in the formulation. Retinol+ is designed to deliver ingredients deep in the skin dermis, minimising thus the drying of the skin. Nonetheless, if you feel that your skin is getting dry, use a moisturizing product (e.g. a moisturizing night cream) with your therapy.
If you have Oily Skin, take into account that retinol effectively controls oil production and oily skins may tolerate higher doses of retinol.
If you have a Sensitive Skin, take into account that Retinol+ is formulated especially to care for sensitive skins. Retinol+ does not contain any sensitising materials, aromas, parabens or genetically modified ingredients. The Retinol content of Retinol+ formulation is meticulously selected as to exert full activity without providing risks to sensitive skins.
If you have acne-prone skin, take into consideration that Retinol+ can effectively improve your condition because of its exfoliating activity.
If you have Dry skin, consider using a good moisturizer in parallel with Retinol+.
Preferably use sunscreens if you are engaged in outdoor activities during the day (at least SPF 15).
Use of products with antioxidants (oral and/or topical), such as Vitamin C, Vitamin E, Co Q10, Green Tea, etc. is usually recommended in parallel to the use of Retinol products. With Retinol+ therapy, such complimenting activity is not routinely required, since Retinol+ already contains antioxidant ingredients (DMM Chromanol).
However, a product everyone must use as from the age of around 30, when expression lines make their initial appearance on skin, is EXPRESSION WRINKLES REDUCER. This product to effectively reduces the appearance of expression wrinkles, and is a monodose advanced formulation with 10 % ARGIRELINE®.
Skin ageing is a very complex, multi-factorial process, continuously researched by scientists. The results of skin ageing are abnormal changes to the cells and tissues of the skin and lower skin layers (Epidermis and Dermis). Changes in Dermis (lower skin layer) make a much greater contribution to the overall appearance of the skin, though skin ageing is also apparent in Epidermis.
Sun exposure is responsible of almost 90% of premature skin ageing usually referred to as photoaging (all external factors responsible for skin ageing are referred as “extrinsic” ageing in contrast to normal skin ageing, referred also as “intrinsic” ageing). Photo damaging starts early in life and has a cumulative activity. UV radiation is without doubt the single major factor responsible for skin ageing.
The main clinical signs of photoaging are changes/irregular pigmentation, swollenness, deep wrinkles dryness, skin atrophy, skin roughness, laxity, telangiectasias, and premalignant lesions. These changes appear on the sun exposed areas of our body, such as face, neck, upper chest, hands and forearms. These changes are more visible when we compare people working outdoors (farmers, sailors, sunbathers, outdoor activities) and people working indoors.
In contrast, normal skin ageing (also known as “intrinsic” ageing) is characterised mainly by fine wrinkles, laxity, seborrheic keratosis (Not increased pigmentation and deep wrinkles that characterise photoaging).
UV radiation of sun light absorbed by skin, damages the DNA and generates some harmful substances (called Reactive Oxygen Species) that eventually decrease the number of fibroblasts, reduce the synthesis of elastin, and increase the breakdown of collagen and the formation of deep wrinkles.
Retinol+ effectively reverses photo damages generated by sunlight, which are responsible for the formation of deep wrinkles up to 90%.
Increased life expectancy and modern life-style (entertainment, summer vacations, etc.) are factors contributing to the appearance of skin ageing. Tobacco smoke, environmental pollution, malnutrition, alcohol consumption also contribute to premature skin ageing and wrinkles.
Genetic factors determine to some extent the early or late appearance of skin ageing. But, almost 90% of skin ageing is due to sun induced skin damages (Photoaging) and more specifically by UV radiation.
The main proposed mechanism of photo damage is the deleterious effect of UV radiation to the DNA by Reactive Oxygen Species (ROS), i.e. free radicals that are produced by UV damaged cells (oxidative cell metabolism). Free radicals damage the skin’s DNA, lipids and proteins, including Collagen. Collagen is responsible for skin’s integrity, firmness and elasticity. Damaging collagen leads to premature skin-ageing and the formation of wrinkles.
Sex hormones deficiency such as estrogen and progesterone (e.g. menopause) and testosterone cause skin dryness, wrinkles, epidermal atrophy, collagen breakdown and loss of elasticity.
Repetitive face movements may promote the appearance of wrinkles e.g. around the eyes -“crows feet”-, forehead, around the mouth, between eyebrows etc.
Sun Avoidance
Best practice is to avoid as much as possible exposure to sunlight (UVA and UVB radiation). More importantly, avoid sun exposure between 10:00 – 16:00 (midday) when sunlight is most intense. Avoid sunbathing and sun tanning beds which accelerate photoaging (“There is no such thing as a healthy tan”!).
Sunscreens
Use sunscreens when you are exposed to sunlight. Sunscreens efficacy is defined by their Sun Protection Factor (SPF). Use good quality sunscreens with an SPF of 15 or higher and apply frequently (every 2-3 hours) to all exposed body parts.
Take into consideration that SPF rating only confers protection against UVB and NOT against UVA. UVA blockers are nowadays available. Total blockers (such as Titanium dioxide and Zinc oxide) which are physical blockers or newer organic filters cover both UVA and UVB radiation spectrum.
Clothing
Consider wearing a hat, long sleeved, light coloured clothing of suitable materials that block UV radiation and allow the body to breathe.
Yes, there is! A vast number of articles, scientific studies, including clinical studies [double blind, placebo (vehicle)-controlled], were published proving the efficacy of Retinol in prevention and treatment of lines, wrinkles, skin ageing and in supporting acne treatment.
Well known are the studies conducted by the University of Michigan, proving retinol effectiveness, which shed more light on the mechanism of action (retinoic acid skin receptors).
The most powerful evidence in cosmetics effectiveness is clinical studies. A brief list of such studies proving the efficacy of Retinol follows:
1) Tucker-Samaras et al. A stabilized 0.1% retinol facial moisturizer improves the appearance of photo damaged skin in an eight-week, double blind, vehicle –controlled study. J Drugs Dermatol. 2009 Oct; 8(10):932-6
2) R.Kfi et al. Improvement of naturally aged skin with Vitamin A (Retinol) Arch Dermatol.2007; 143(5): 606-612
3) C.Stephanaki et al. Topical retinoids in the treatment of photoaging. J. Cosm. Dermatol.2005,4, 130-134.
4) Y.Shao et al. Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo.Int.J.Cosmet.Sci.2017, 39, 56-65
5) D.Rossetti et al. A novel anti-ageing mechanism for retinol: induction of dermal elastin synthesis and elastin fibre formation. Int.J.Cosmet.Sci.2011, 33, 62-69.
6) C.Zouboulis. Retinoids: Is there a new approach IFSCC Magazine-vol.3, no3/2000, 9-19
7) C.Ruamrak et al. Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment. Int.J.Cosmet. Sci. 2009, 31, 41-46.
8) J.Varani et al. Molecular mechanisms of intrinsic skin aging and retinoid-induced repair and reversal. 1998 .JID symposium proceedings.
9) R.Darlenski et al. Topical retinoids in the management of photo damage skin: From theory to evidence-based practical approach. Brit. J. Derm. 2010; 163 (6): 1157-1165
10) J.Varani et al. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin
J. Invest. Derm. 2000; 114 (3): 480-486
Worldwide there are no limits in the permitted concentration of Retinol to be used in cosmetic products with the exception of Canada whereas is permitted in concentrations equals or less than 1%.
However the Scientific Committee on Consumer Safety (SCCS) of the European Commission on OCT’ 06 . 2016 has concluded that Retinol is safe when used as cosmetic ingredient in face care products at the maximum concentration of 0.3 %.
It must be noted that this opinion has not affected yet any EU regulatory restrictions.
With thousands upon thousands of creams, serums etc claiming to turn back the clock at your skin, there’s only one active ingredient that really delivers on its promise Retinol.
Retinol is perhaps the best performing ingredient to effectively address the signs of premature ageing and photo damaged skin.
Retinol is able to tackle several different skin concerns at once including sun damage, fine lines, pores, acne prone skin and overall texture.
Retinol increases cell turnover, stimulates collagen and elastin production leaving your skin well hydrated, smoother and by inhibiting the production of melanin your skin is more luminous.
In conclusion Retinol it’s the closest thing to skincare miracle you’ll find.
